Anne Müller

Anne Müller, Prof. Dr.

Chair of the Board of Directors

Curriculum vitae

Education / Positions

1990-1996 M.S. Biology. Julius-Maximilians-Universitaet Wuerzburg, Germany

1996-2000 Ph.D. in Microbiology, Max Planck Institute for Infection Biology, Dept. of Molecular Biology, Berlin, Germany

2000-2001 Post-doctoral Fellow, Max Planck Institute for Infection Biology, Dept. of Molecular Biology, Berlin, Germany

2001-2006 Post-doctoral Fellow, Stanford University School of Medicine, Dept. of Microbiology and Immunology, Stanford, CA, USA

2006-2012 Assistant Professor, Institute for Molecular Cancer Research, University of Zurich, Switzerland

Since 2012 Associate Professor of Experimental Medicine, Institute for Molecular Cancer Research, University of Zurich, Switzerland

Since 2017 Chair of the Board of Directors, Institute for Molecular Cancer Research, University of Zurich, Switzerland

Research Experience / Interest

Animal models of human cancers

Virulence factors of Helicobacter pylori and their contribution to colonization, persistence and pathogenesis

Molecular pathogenesis of gastric cancer: normal cell counterparts and precursor lesions

Tumor markers for gastric cancer and Helicobacter-induced mucosa associated lymphoid tissue (MALT) lymphoma

Helicobacter pylori and gastric cancer: role of bacterial and host factors in tumor formation

MicroRNA and their role in cancer

Fellowships / Awards

1996-1999 Pre-doctoral Fellowship, Max Planck Society

2001 Otto Hahn young investigators’ Award, Max Planck Society

2001 Dissertation Award, German Society for Hygiene and Microbiology

2001-2002 Otto Hahn Post-doctoral Fellowship, Max Planck Society

2002-2004 Post-doctoral Research Fellowship, German Research Foundation (DFG)

2012 Georg Friedrich Götz Prize of the University of Zurich


Kyburz, Andreas; Müller, Anne (2017). Helicobacter pylori and Extragastric Diseases. In: Tegtmeyer, Nicole; Backert, Steffen. Molecular Pathogenesis and Signal Transduction by Helicobacter pylori. Springer International Publishing: Springer, 325-347.

Mejías-Luque, Raquel; Zöller, Jessica; Anderl, Florian; Loew-Gil, Elena; Vieth, Michael; Adler, Thure; Engler, Daniela B; Urban, Sabine; Browning, Jeffrey L; Müller, Anne; Gerhard, Markus; Heikenwalder, Mathias (2016). Lymphotoxin β receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner. Gut:Epub ahead of print.

Smits, Hermelijn H; Hiemstra, Pieter S; Prazeres da Costa, Clarissa; Ege, Markus; Edwards, Michael; Garn, Holger; Howarth, Peter H; Jartti, Tuomas; de Jong, Esther C; Maizels, Rick M; Marsland, Ben J; McSorley, Henry J; Müller, Anne; Pfefferle, Petra I; Savelkoul, Huub; Schwarze, Jürgen; Unger, Wendy W J; von Mutius, Erika; Yazdanbakhsh, Maria; Taube, Christian (2016). Microbes and asthma: Opportunities for intervention. Journal of Allergy and Clinical Immunology, 137(3):690-697.

Flori, Michael; Schmid, Corina A; Sumrall, Eric T; Tzankov, Alexandar; Law, Charity W; Robinson, Mark D; Müller, Anne (2016). The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. Blood, 127(11):1438-1448.

Arnold, Isabelle C; Müller, Anne (2016). Helicobacter pylori: does gastritis prevent colitis? Inflammatory Intestinal Diseases, 1(3):102-112.

Pachathundikandi, Suneesh Kumar; Müller, Anne; Backert, Steffen (2016). Inflammasome activation by helicobacter pylori and its implications for persistence and immunity. In: Backert, Steffen. Inflammasome Signaling and Bacterial Infections. Germany: Springer, 117-131.

Kyburz, Andreas; Müller, Anne (2016). The gastrointestinal tract microbiota and allergic diseases. Digestive Diseases, 34(3):230-243.

Koch, Katrin N; Müller, Anne (2015). Helicobacter pylori activates the TLR2/NLRP3/caspase-1/IL-18 axis to induce regulatory T-cells, establish persistent infection and promote tolerance to allergens. Gut Microbes, 6(6):382-387.

Hartung, Mara L; Gruber, Dorothea C; Koch, Katrin N; Grüter, Livia; Rehrauer, Hubert; Tegtmeyer, Nicole; Backert, Steffen; Müller, Anne (2015). H. pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote nf-κb target gene expression. Cell Reports, 13(1):70-79.

Koch, Katrin N; Hartung, Mara L; Urban, Sabine; Kyburz, Andreas; Bahlmann, Anna S; Lind, Judith; Backert, Steffen; Taube, Christian; Müller, Anne (2015). Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma. Journal of Clinical Investigation, 125(8):3297-3302.

Schmid, Corina A; Robinson, Mark D; Scheifinger, Nicole A; Müller, Sebastian; Cogliatti, Sergio; Tzankov, Alexandar; Müller, Anne (2015). DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma. Journal of Experimental Medicine:1-18.

Engler, Daniela B; Leonardi, Irina; Hartung, Mara L; Kyburz, Andreas; Spath, Sabine; Becher, Burkhard; Rogler, Gerhard; Müller, Anne (2015). Helicobacter pylori-specific Protection Against Inflammatory Bowel Disease Requires the NLRP3 Inflammasome and IL-18. Inflammatory Bowel Diseases, 21(4):854-861.

Semper, Raphaela P; Mejías-Luque, Raquel; Groß, Christina; Anderl, Florian; Müller, Anne; Vieth, Michael; Busch, Dirk H; Prazeres da Costa, Clarissa; Ruland, Jürgen; Groß, Olaf; Gerhard, Markus (2014). Helicobacter pylori-Induced IL-1β Secretion in Innate Immune Cells Is Regulated by the NLRP3 Inflammasome and Requires the Cag Pathogenicity Island. Journal of Immunology, 193(7):3566-3576.

Engler, Daniela B; Reuter, Sebastian; van Wijck, Yolanda; Urban, Sabine; Kyburz, Andreas; Maxeiner, Joachim; Martin, Helen; Yogev, Nir; Waisman, Ari; Gerhard, Markus; Cover, Timothy L; Taube, Christian; Müller, Anne (2014). Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Proceedings of the National Academy of Sciences of the United States of America:1-6.

Schmid, Corina; Müller, Anne (2013). FoxD3 is a novel, epigenetically regulated tumor suppressor in gastric carcinogenesis. Gastroenterology, 144(1):22-25.

Oertli, Mathias; Noben, Manuel; Engler, Daniela B; Semper, Raphaela P; Reuter, Sebastian; Maxeiner, Joachim; Gerhard, Markus; Taube, Christian; Müller, Anne (2013). Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance. Proceedings of the National Academy of Sciences of the United States of America, 110(8):3047-3052.

Salama, Nina R; Hartung, Mara L; Müller, Anne (2013). Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nature Reviews. Microbiology, 11(6):385-399.

Schmid, Corina A; Craig, Vanessa J; Müller, Anne; Flori, Michael (2013). The role of microRNAs in the pathogenesis and treatment of hematopoietic malignancies. Current Pharmaceutical Design, 19(7):1201-1210.

Hitzler, Iris; Sayi, Ayca; Kohler, Esther; Engler, Daniela B; Koch, Katrin N; Hardt, Wolf-Dietrich; Müller, Anne (2012). Caspase-1 has both pro-inflammatory and regulatory properties in Helicobacter Infections, which are differentially mediated by its substrates IL-1β and IL-18. Journal of Immunology, 188(8):3594-3602.

Oertli, Mathias; Müller, Anne (2012). Helicobacter pylori targets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma. Gut Microbes, 3(6):566-571.

Müller, Anne (2012). Multistep activation of the Helicobacter pylori effector CagA. Journal of Clinical Investigation, 122(4):1192-1195.

Arnold, Isabelle C; Hitzler, Iris; Müller, Anne (2012). The Immunomodulatory Properties of Helicobacter pylori Confer Protection Against Allergic and Chronic Inflammatory Disorders. Frontiers in Cellular and Infection Microbiology, 2(10):online.

Taube, Christian; Müller, Anne (2012). The role of Helicobacter pylori infection in the development of allergic asthma. Expert Review of Respiratory Medicine, 6(4):441-449.

Hitzler, Iris; Kohler, Esther; Engler, Daniela B; Yazgan, Ayca S; Müller, Anne (2012). The role of Th cell subsets in the control of Helicobacter infections and in T cell-driven gastric immunopathology. Frontiers in Immunology, 3:142.

Craig, V.J., Tzankov, A., Flori, M., Schmid, C., Bader, A.G., and Müller, A. Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo. In press, Leukemia.(2012)

Oertli M, Sundquist M, Hitzler I, Engler DB, Arnold IC, Reuter S, Maxeiner J, Hansson M, Taube C, Quiding-Järbrink M, Müller A. DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection.J Clin Invest. 2012 Mar 1;122(3):1082-96.

Müller, A; Solnick, J V (2011). Inflammation, immunity, and vaccine development for Helicobacter pylori. Helicobacter, 16 (Sup 1):26-32.

Müller, A; Oertli, M; Arnold, I C (2011). H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection. Cell Communication and Signaling, 9(1):25.

Sayi, A., Kohler, E., Toller, I., Flavell, R.A., Müller, W., Roehrs, A. and Müller, A. TLR-2-activated B-cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing Tr-1 cells in a CD40/CD40L-dependent manner. Journal of Immunology 186, 878-90 (2011).

Hitzler, I., Oertli, M., Becher, B., Agger, E.M. and Müller, A. Dendritic cells prevent rather than promote immunity conferred by a novel mycobacterially adjuvanted Helicobacter vaccine. Gastroenterology 141:186-196 (2011). 

Arnold, I.C., Hitzler, I., Engler, D.B., Oertli, M., Agger, E.M. and Müller, A. The T-cell antigenicity of the Helicobacter pylori virulence factor CagA promotes gastric preneoplasia. Journal of Immunology 186, 6165-72 (2011).

Arnold, I.C., Dehzad, N., Reuter, S., Martin, H., Becher, B., Taube, C. and Müller, A. Neonatal infection with Helicobacter pylori prevents asthma through impaired dendritic cell maturation and induction of regulatory T-cells. Journal of Clinical Investigation 121:3088–3093 (2011).

Craig, V.J., Cogliatti, S.B., Imig, J., Renner, C., Neuenschwander, S., Rehrauer, H., Schlapbach, R., Tzankov, A., Dirnhofer, S. and Müller, A. Myc-mediated repression of microRNA-34a promotes high grade transformation of gastric B-cell lymphoma by dysregulation of FoxP1. Blood 117, 6227-6236 (2011).

Craig, V.J., Cogliatti, S.B., Rehrauer, H., Wündisch, T. and Müller, A. Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric MALT lymphomagenesis. Cancer Research 71, 3616-24 (2011). 

Arnold, I.C., Zigova, Z., Holden, M., Lawley, T.D., Rad, R., Dougan, G., Falkow, S., Bentley, S.D. and Müller, A. Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen Helicobacter felis. Genome Biology and Evolution 3, 302-8 (2011).

Toller. I.M., Neelsen, K., Steger, M., Hottiger, M.O., Stucki, M., Gerhard, M., Sartori, A.A., Lopes, M. and Müller, A. The carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double strand breaks and a DNA damage response in infected host cells. PNAS 108, 14944-14949 (2011). 

Oertli, M., Engler, D.B., Kohler, E., Koch, M., Meyer, T.F., and Müller, A. MicroRNA-155 is essential for the T-cell mediated control of Helicobacter pylori infection and for the induction of chronic gastritis and colitis. Journal of Immunology 187, 3578-86 (2011). 

Arnold, I., Lee, J.Y., Amieva, M.R., Flavell, R.A., Sparwasser, T. and Müller, A. Tolerance rather than immunity protects from Helicobacter-induced gastric preneoplasia. Gastroenterology 140, 199–209 (2011). 

Toller, I., Hitzler, I., Sayi, A. and Müller, A. ProstaglandinE2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model. Gastroenterology 138, 1455–1467(2010). 

Craig, V., Arnold, I., Gerke, C., Huynh, M.Q., Wündisch, T., Neubauer, A., Falkow, S. and Müller, A. Gastric MALT lymphoma B-cells express polyreactive, somatically mutated immunoglobulins. Blood 115, 581-91 (2010). 

Craig, V.J., Cogliatti, S.B., Arnold, I., Gerke, C., Balandat, J.E., Wündisch, T. and Müller, A. B-cell receptor signaling and CD40 ligand-independent T-cell help cooperate in Helicobacter-induced MALT lymphomagenesis. Leukemia 24, 1186-96 (2010).

Toller, I.M., Altmeyer, M., Kohler, E., Hottiger, M.O. and Müller, A. Inhibition of ADP-ribosylation prevents and cures Helicobacter-induced gastric preneoplasia. Cancer Research 70, 5912-22 (2010). 

Sayi, A., Kohler,, E., Hitzler, I., Arnold, I., Schwendener, R., Rehrauer, H. and Müller, A. The CD4+ T-cell-mediated Interferon-γ response to Helicobacter infection is essential for clearance and determines gastric cancer risk. Journal of Immunol. 182, 7085-101 (2009). 

Rechner, C., Kuehlewein, C., Müller, A., Schild, HJ. And Rudel, T. Gp96 and SREC interact with PorBIA to modulate adherence and invasion of disseminating Neisseria gonorrhoeae. Cell Host and Microbe 13, 393-403 (2007). 

Müller, A., O’Rourke, J., Chu, P., Lee, A. and Falkow, S. The role of Helicobacter pylori and H. pylori-specific T-cells in MALT lymphoma pathogenesis. American Journal of Pathology 167, 797-812 (2005). 

Grimm, J., Müller, A., Hefti, F. and Rosenthal, A. Molecular basis for catecholaminergic neuron diversity. Proc. Natl. Acad. Sci. 101, 13891-13896 (2004). 

El-Etr, S.H., Müller, A., Tompkins, L.S., Falkow, S. and Merrell, D.S. Phosphorylation-Independent Effects of CagA During Interaction of H. pylori with Polarized T84 Monolayers. J. Inf. Dis. 190, 1516-1523 (2004). 

Müller, A., Merrell, D.S., Grimm, J. and Falkow, S. Profiling of microdissected gastric epithelial cells reveals a cell type specific response to Helicobacter pylori infection. Gastroenterology 127, 1446-1462 (2004). 

Müller, A., Grimm, J., O’Rourke, J., Lee, A., Guillemin, K., Dixon, M.F. and Falkow, S. Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Proc. Natl. Acad. Sci. 100, 1292-1297 (2003). 

Müller, A., O’Rourke, J., Chu, P., Kim, C.C., Sutton, P., Lee, A. and Falkow, S. Protective immunity against Helicobacter is characterized by a unique transcriptional signature. Proc. Natl. Acad. Sci. 100, 12289-12294 (2003). 

Müller, A., Rassow, J., Grimm, J., Machuy, N., Meyer, T.F. and Rudel, T. VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways. EMBO J. 21, 1916-1929 (2002). 

Rajalingam, K., Alyounes, H., Müller, A., Meyer, T.F., Szczepek, A.J. and Rudel, T. Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Inf. Imm. 69, 7880-7888 (2001). 

Müller, A., Günther, D., Brinkmann, V., Hurwitz, R., Meyer, T.F. and Rudel, T. Pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae is targeted to the mitochondria of infected cells. EMBO J. 19, 5332-5343 (2000).

Müller, A., Günther, D., Düx, F., Naumann, M., Meyer, T.F. and Rudel, T. Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases. EMBO J. 18, 339-352 (1999). 

Müller, A., Hacker, J. and Brand, B. Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection. Inf. Imm. 64 (12), 4900-4906 (1996). 

Review articles

Salama, Nina R; Hartung, Mara L; Müller, Anne (2013). Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nature Reviews. Microbiology: 11(6):385-99

Arnold, I.C., Hitzler, I. and Müller, A. The immunomodulatory properties of Helicobacter pylori confer protection against allergic and chronic inflammatory disorders. Frontiers in Cellular and Infection Microbiol. 2:10. (2012)

Müller, A. Multi-step activation of the Helicobacter pylori effector CagA. Journal of Clinical Investigation 122, 1192-5.(2012)

Schmid C, Müller A. FoxD3 Is a Novel, Epigenetically Regulated Tumor Suppressor in Gastric Carcinogenesis. Gastroenterology. 2012 Nov 16; 144(1):22-25.

Müller, A. and Solnick, J. Inflammation, Immunity and Vaccines for Helicobacter. Helicobacter 2011 Sep;16, 26-32.

Müller, A., Oertli, M. and Arnold, I.C. H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection. Cell Communication and Signaling, 9, 25(2011).

Müller, A., Sayi, A. and Hitzler, I. Protective and pathogenic functions of T-cells are inseparable during the Helicobacter-host interaction. Discovery Medicine 8, 68-73 (2009).

Müller, A., Falkow, S. and Amieva, M.R. Helicobacter pylori and gastric cancer: what can be learned by studying the response of gastric epithelial cells to the infection? Special gastric cancer edition of Cancer Epidemiology, Prevention and Biomarkers 14, 1859-1964 (2005).

Monack, D., Müller, A. and Falkow, S. Persistent bacterial infections: the interface of the pathogen and the host immune system. Nature Rev. Microbiol. 2, 747-765 (2004). 

Müller A. and Rudel T. Modification of host cell apoptosis by viral and bacterial pathogens Int. J. Med. Microbiol. 291, 197-207 (2001). 

Book chapter

Müller A. The pathogenesis of MALT lymphoma. One chapter in a text book on gastric cancer. Springer University Press. (2008).