HELICOBACTER PYLORI AND GASTRIC CANCER

Our laboratory is interested in elucidating the mechanisms linking chronic inflammation to carcinogenesis. Our model system is the infectious agent Helicobacter pylori, which persistently colonizes the human stomach and causes gastritis, ulcers and gastric cancer. We use cell culture and animal models to study the immune response to the infection, but also to dissect how bacterial virulence factors and host factors such as the age at time of infection influence disease outcome.