Institute of Molecular Cancer Research

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University of Zurich
Institute of Molecular Cancer Research
Winterthurerstrasse 190
CH-8057 Zurich
Switzerland

DIRECTOR
Prof. Dr. Josef Jiricny

CONTACT
Luterbacher Danielle
phone: +41 (0)44 635 34 51
fax: +41 (0)44 635 34 84

UPCOMING EVENTS

Seminars
4.4.2016
Niels Mailand, University of Copenhagen, Denmark

a

Scientific Report

Universität Zürich - Campus Info

Institute of Molecular Cancer Research

b


NEWS

j
j
Matteo Berti and Stanislaw Jozwiakowski were awarded a Marie-Skłodowska Curie Fellowship.

c
Petr Cejka was awarded the Ernst Th. Jucker Prize 2015.



RECENT PUBLICATIONS

Flori, Michael; Schmid, Corina A; Sumrall, Eric T; Tzankov, Alexandar; Law, Charity W; Robinson, Mark D; Müller, Anne (2016). The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. Blood:Epub ahead of print.

Flori, Michael. The hematopoietic oncoprotein FOXP1 promotes cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. 2016, University of Zurich, Faculty of Science.

Koch, Katrin N; Müller, Anne (2015). Helicobacter pylori activates the TLR2/NLRP3/caspase-1/IL-18 axis to induce regulatory T-cells, establish persistent infection and promote tolerance to allergens. Gut Microbes, 6(6):382-387.

Hartung, Mara L; Gruber, Dorothea C; Koch, Katrin N; Grüter, Livia; Rehrauer, Hubert; Tegtmeyer, Nicole; Backert, Steffen; Müller, Anne (2015). H. pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote nf-κb target gene expression. Cell Reports, 13(1):70-79.

Anstaett, Philipp; Pierroz, Vanessa; Ferrari, Stefano; Gasser, Gilles (2015). Two-photon uncageable enzyme inhibitors bearing targeting vectors. Photochemical & Photobiological Sciences, 14(10):1821-1825.

Fontana, Andrea O; Augsburger, Marc A; Grosse, Nicole; Guckenberger, Matthias; Lomax, Anthony J; Sartori, Alessandro A; Pruschy, Martin N (2015). Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation. Radiotherapy and Oncology, 116(3):374-380.

Burdova, Kamila; Mihaljevic, Boris; Sturzenegger, Andreas; Chappidi, Nagaraja; Janscak, Pavel (2015). The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks. Molecular Cell, 59(4):603-614.

Koch, Katrin N; Hartung, Mara L; Urban, Sabine; Kyburz, Andreas; Bahlmann, Anna S; Lind, Judith; Backert, Steffen; Taube, Christian; Müller, Anne (2015). Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma. Journal of Clinical Investigation, 125(8):3297-3302.

Bologna, Serena; Altmannova, Veronika; Valtorta, Emanuele; Koenig, Christiane; Liberali, Prisca; Gentili, Christian; Anrather, Dorothea; Ammerer, Gustav; Pelkmans, Lucas; Krejci, Lumir; Ferrari, Stefano (2015). Sumoylation regulates EXO1 stability and processing of DNA damage. Cell Cycle, 14(15):2439-2450.

Cejka, Petr (2015). DNA end resection: nucleases team up with the right partners to initiate homologous recombination. Journal of Biological Chemistry:1-18.

Pizzolato, Julia; Mukherjee, Shivam; Schaerer, Orlando D; Jiricny, Josef (2015). FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro. Journal of Biological Chemistry:1-20.

Levikova, Maryna; Cejka, Petr (2015). The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication. Nucleic Acids Research, 15(1):1-10.

Gemble, Simon; Ahuja, Akshay; Buhagiar-Labarchède, Géraldine; Onclercq-Delic, Rosine; Dairou, Julien; Biard, Denis S F; Lambert, Sarah; Lopes, Massimo; Amor-Guéret, Mounira (2015). Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA. PLoS Genetics, 11(7):e1005384.

Schmid, Corina A; Robinson, Mark D; Scheifinger, Nicole A; Müller, Sebastian; Cogliatti, Sergio; Tzankov, Alexandar; Müller, Anne (2015). DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma. Journal of Experimental Medicine:1-18.

Engler, Daniela B; Leonardi, Irina; Hartung, Mara L; Kyburz, Andreas; Spath, Sabine; Becher, Burkhard; Rogler, Gerhard; Müller, Anne (2015). Helicobacter pylori-specific Protection Against Inflammatory Bowel Disease Requires the NLRP3 Inflammasome and IL-18. Inflammatory Bowel Diseases, 21(4):854-861.

Fugger, Kasper; Mistrik, Martin; Neelsen, Kai J; Yao, Qi; Zellweger, Ralph; Kousholt, Arne Nedergaard; Haahr, Peter; Chu, Wai Kit; Bartek, Jiri; Lopes, Massimo; Hickson, Ian D; Sørensen, Claus Storgaard (2015). FBH1 Catalyzes Regression of Stalled Replication Forks. Cell Reports, 10(10):1749-1757.

Thangavel, Saravanabhavan; Berti, Matteo; Levikova, Maryna; Pinto, Cosimo; Gomathinayagam, Shivasankari; Vujanovic, Marko; Zellweger, Ralph; Moore, Hayley; Lee, Eu Han; Hendrickson, Eric A; Cejka, Petr; Stewart, Sheila; Lopes, Massimo; Vindigni, Alessandro (2015). DNA2 drives processing and restart of reversed replication forks in human cells. Journal of Cell Biology, 208(5):545-562.

Zellweger, Ralph; Dalcher, Damian; Mutreja, Karun; Berti, Matteo; Schmid, Jonas A; Herrador, Raquel; Vindigni, Alessandro; Lopes, Massimo (2015). Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. Journal of Cell Biology, 208(5):563-579.

Neelsen, Kai J; Lopes, Massimo (2015). Replication fork reversal in eukaryotes: from dead end to dynamic response. Nature Reviews. Molecular Cell Biology, 16(4):207-220.

Fasching, Clare L; Cejka, Petr; Kowalczykowski, Stephen C; Heyer, Wolf-Dietrich (2015). Top3-rmi1 dissolve rad51-mediated d loops by a topoisomerase-based mechanism. Molecular Cell, 57(4):595-606.

Repmann, Simone; Olivera-Harris, Maite; Jiricny, Josef (2015). Influence of Oxidized Purine Processing on Strand Directionality of Mismatch Repair. Journal of Biological Chemistry, 290(16):9986-9999.

Fumasoni, Marco; Zwicky, Katharina; Vanoli, Fabio; Lopes, Massimo; Branzei, Dana (2015). Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex. Molecular Cell:1-13.

Olivera Harris, Maite; Kallenberger, Lia; Artola Borán, Mariela; Enoiu, Milica; Costanzo, Vincenzo; Jiricny, Josef (2015). Mismatch repair-dependent metabolism of O(6)-methylguanine-containing DNA in Xenopus laevis egg extracts. DNA repair, 28C:1-7.

Gentili, Christian; Castor, Dennis; Kaden, Svenja; Lauterbach, David; Gysi, Mario; Steigemann, Patrick; Gerlich, Daniel W; Jiricny, Josef; Ferrari, Stefano (2015). Chromosome Missegregation Associated with RUVBL1 Deficiency. PLoS ONE, 10(7):e0133576.

Mari, Cristina; Pierroz, Vanessa; Ferrari, Stefano; Gasser, Gilles (2015). Combination of Ru(II) Complexes and Light: New Frontiers in Cancer Therapy. Chemical Science, 6:2660-2686.

Csefalvay, Eva; Lapkouski, Mikalai; Guzanova, Alena; Csefalvay, Ladislav; Baikova, Tatsiana; Shevelev, Igor; Bialevich, Vitali; Shamayeva, Katsiaryna; Janscak, Pavel; Kuta Smatanova, Ivana; Panjikar, Santosh; Carey, Jannette; Weiserova, Marie; Ettrich, Rüdiger (2015). Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme. PLoS ONE, 10(6):e0128700.

Leonidova, Anna; Anstaett, Philipp; Pierroz, Vanessa; Spingler, Bernhard; Ferrari, Stefano; Gasser, Gilles (2015). Induction of Cytotoxicity through Photo-release of Aminoferrocene. Inorganic Chemistry, 54:9740-9748.

Mari, Cristina; Pierroz, Vanessa; Leonidova, Anna; Ferrari, Stefano; Gasser, Gilles (2015). Towards Selective Light Activated Ru(II)-based Prodrug Candidates. European Journal of Inorganic Chemistry, 23:3879-3891.

Hühn, D; Kousholt, A N; Sørensen, C S; Sartori, A A (2015). miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene, 34(30):3977-3984.