Institute of Molecular Cancer Research

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Prof. Dr.  Anne  Müller
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Curriculum vitae

Education / Positions

1990-1996 M.S. Biology. Julius-Maximilians-Universitaet Wuerzburg, Germany

1996-2000 Ph.D. in Microbiology, Max Planck Institute for Infection Biology, Dept. of Molecular Biology, Berlin, Germany

2000-2001 Post-doctoral Fellow, Max Planck Institute for Infection Biology, Dept. of Molecular Biology, Berlin, Germany

2001-2006 Post-doctoral Fellow, Stanford University School of Medicine, Dept. of Microbiology and Immunology, Stanford, CA, USA

2006-2012 Assistant Professor, Institute for Molecular Cancer Research, University of Zurich, Switzerland

Since 2012 Associate Professor of Experimental Medicine, Institute for Molecular Cancer Research, University of Zurich, Switzerland

Research Experience / Interest

Animal models of human cancers

Virulence factors of Helicobacter pylori and their contribution to colonization, persistence and pathogenesis

Molecular pathogenesis of gastric cancer: normal cell counterparts and precursor lesions

Tumor markers for gastric cancer and Helicobacter-induced mucosa associated lymphoid tissue (MALT) lymphoma

Helicobacter pylori and gastric cancer: role of bacterial and host factors in tumor formation

MicroRNA and their role in cancer

Fellowships / Awards

1996-1999 Pre-doctoral Fellowship, Max Planck Society

2001 Otto Hahn young investigators’ Award, Max Planck Society

2001 Dissertation Award, German Society for Hygiene and Microbiology

2001-2002 Otto Hahn Post-doctoral Fellowship, Max Planck Society

2002-2004 Post-doctoral Research Fellowship, German Research Foundation (DFG)

2012 Georg Friedrich Götz Prize of the University of Zurich

Publications

Müller, A., Hacker, J. and Brand, B. Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection. Inf. Imm. 64 (12), 4900-4906 (1996). 

Müller, A., Günther, D., Düx, F., Naumann, M., Meyer, T.F. and Rudel, T. Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases. EMBO J. 18, 339-352 (1999). 

Müller, A., Günther, D., Brinkmann, V., Hurwitz, R., Meyer, T.F. and Rudel, T. Pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae is targeted to the mitochondria of infected cells. EMBO J. 19, 5332-5343 (2000).

Rajalingam, K., Alyounes, H., Müller, A., Meyer, T.F., Szczepek, A.J. and Rudel, T. Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Inf. Imm. 69, 7880-7888 (2001). 

Müller, A., Rassow, J., Grimm, J., Machuy, N., Meyer, T.F. and Rudel, T. VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways. EMBO J. 21, 1916-1929 (2002). 

Müller, A., Grimm, J., O’Rourke, J., Lee, A., Guillemin, K., Dixon, M.F. and Falkow, S. Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Proc. Natl. Acad. Sci. 100, 1292-1297 (2003). 

Müller, A., O’Rourke, J., Chu, P., Kim, C.C., Sutton, P., Lee, A. and Falkow, S. Protective immunity against Helicobacter is characterized by a unique transcriptional signature. Proc. Natl. Acad. Sci. 100, 12289-12294 (2003). 

Grimm, J., Müller, A., Hefti, F. and Rosenthal, A. Molecular basis for catecholaminergic neuron diversity. Proc. Natl. Acad. Sci. 101, 13891-13896 (2004). 

El-Etr, S.H., Müller, A., Tompkins, L.S., Falkow, S. and Merrell, D.S. Phosphorylation-Independent Effects of CagA During Interaction of H. pylori with Polarized T84 Monolayers. J. Inf. Dis. 190, 1516-1523 (2004). 

Müller, A., Merrell, D.S., Grimm, J. and Falkow, S. Profiling of microdissected gastric epithelial cells reveals a cell type specific response to Helicobacter pylori infection. Gastroenterology 127, 1446-1462 (2004). 

Müller, A., O’Rourke, J., Chu, P., Lee, A. and Falkow, S. The role of Helicobacter pylori and H. pylori-specific T-cells in MALT lymphoma pathogenesis. American Journal of Pathology 167, 797-812 (2005). 

Rechner, C., Kuehlewein, C., Müller, A., Schild, HJ. And Rudel, T. Gp96 and SREC interact with PorBIA to modulate adherence and invasion of disseminating Neisseria gonorrhoeae. Cell Host and Microbe 13, 393-403 (2007). 

Sayi, A., Kohler,, E., Hitzler, I., Arnold, I., Schwendener, R., Rehrauer, H. and Müller, A. The CD4+ T-cell-mediated Interferon-γ response to Helicobacter infection is essential for clearance and determines gastric cancer risk. Journal of Immunol. 182, 7085-101 (2009). 

Toller, I., Hitzler, I., Sayi, A. and Müller, A. ProstaglandinE2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model. Gastroenterology 138, 1455–1467(2010). 

Craig, V., Arnold, I., Gerke, C., Huynh, M.Q., Wündisch, T., Neubauer, A., Falkow, S. and Müller, A. Gastric MALT lymphoma B-cells express polyreactive, somatically mutated immunoglobulins. Blood 115, 581-91 (2010). 

Craig, V.J., Cogliatti, S.B., Arnold, I., Gerke, C., Balandat, J.E., Wündisch, T. and Müller, A. B-cell receptor signaling and CD40 ligand-independent T-cell help cooperate in Helicobacter-induced MALT lymphomagenesis. Leukemia 24, 1186-96 (2010).

Toller, I.M., Altmeyer, M., Kohler, E., Hottiger, M.O. and Müller, A. Inhibition of ADP-ribosylation prevents and cures Helicobacter-induced gastric preneoplasia. Cancer Research 70, 5912-22 (2010). 

Arnold, I., Lee, J.Y., Amieva, M.R., Flavell, R.A., Sparwasser, T. and Müller, A. Tolerance rather than immunity protects from Helicobacter-induced gastric preneoplasia. Gastroenterology 140, 199–209 (2011). 

Sayi, A., Kohler, E., Toller, I., Flavell, R.A., Müller, W., Roehrs, A. and Müller, A. TLR-2-activated B-cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing Tr-1 cells in a CD40/CD40L-dependent manner. Journal of Immunology 186, 878-90 (2011).

Hitzler, I., Oertli, M., Becher, B., Agger, E.M. and Müller, A. Dendritic cells prevent rather than promote immunity conferred by a novel mycobacterially adjuvanted Helicobacter vaccine. Gastroenterology 141:186-196 (2011). 

Arnold, I.C., Hitzler, I., Engler, D.B., Oertli, M., Agger, E.M. and Müller, A. The T-cell antigenicity of the Helicobacter pylori virulence factor CagA promotes gastric preneoplasia. Journal of Immunology 186, 6165-72 (2011).

Arnold, I.C., Dehzad, N., Reuter, S., Martin, H., Becher, B., Taube, C. and Müller, A. Neonatal infection with Helicobacter pylori prevents asthma through impaired dendritic cell maturation and induction of regulatory T-cells. Journal of Clinical Investigation 121:3088–3093 (2011).

Craig, V.J., Cogliatti, S.B., Imig, J., Renner, C., Neuenschwander, S., Rehrauer, H., Schlapbach, R., Tzankov, A., Dirnhofer, S. and Müller, A. Myc-mediated repression of microRNA-34a promotes high grade transformation of gastric B-cell lymphoma by dysregulation of FoxP1. Blood 117, 6227-6236 (2011).

Craig, V.J., Cogliatti, S.B., Rehrauer, H., Wündisch, T. and Müller, A. Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric MALT lymphomagenesis. Cancer Research 71, 3616-24 (2011). 

Arnold, I.C., Zigova, Z., Holden, M., Lawley, T.D., Rad, R., Dougan, G., Falkow, S., Bentley, S.D. and Müller, A. Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen Helicobacter felis. Genome Biology and Evolution 3, 302-8 (2011).

Toller. I.M., Neelsen, K., Steger, M., Hottiger, M.O., Stucki, M., Gerhard, M., Sartori, A.A., Lopes, M. and Müller, A. The carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double strand breaks and a DNA damage response in infected host cells. PNAS 108, 14944-14949 (2011). 

Oertli, M., Engler, D.B., Kohler, E., Koch, M., Meyer, T.F., and Müller, A. MicroRNA-155 is essential for the T-cell mediated control of Helicobacter pylori infection and for the induction of chronic gastritis and colitis. Journal of Immunology 187, 3578-86 (2011). 

Müller, A; Solnick, J V (2011). Inflammation, immunity, and vaccine development for Helicobacter pylori. Helicobacter, 16 (Sup 1):26-32.

Müller, A; Oertli, M; Arnold, I C (2011). H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection. Cell Communication and Signaling, 9(1):25.

Taube C, Müller A. The role of Helicobacter pylori infection in the development of allergic asthma. Expert Rev Respir Med. 2012 Aug;6(4):441-9.

Oertli M, Müller A. Helicobacter pylori targets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma.Gut Microbes. 2012 Nov 1;3(6).

Hitzler I, Kohler E, Engler DB, Yazgan AS, Müller A. The role of Th cell subsets in the control of Helicobacter infections and in T cell-driven gastric immunopathology. Front Immunol. 2012;3:142. Epub 2012 Jun 1.

Craig, V.J., Tzankov, A., Flori, M., Schmid, C., Bader, A.G., and Müller, A. Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo. In press, Leukemia.(2012)

Hitzler, I., Sayi, A., Kohler, E., Engler, D.B., Koch, K.N., Hardt, W.-D. and Müller, A. Caspase-1 has both pro-inflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1β and IL-18. Journal of Immunology doi:10.4049/jimmunol.1103212 (2012).

Oertli M, Sundquist M, Hitzler I, Engler DB, Arnold IC, Reuter S, Maxeiner J, Hansson M, Taube C, Quiding-Järbrink M, Müller A. DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection.J Clin Invest. 2012 Mar 1;122(3):1082-96.

Schmid CA, Craig VJ, Müller A, Flori M. The role of microRNAs in the pathogenesis and treatment of hematopoietic malignancies. Current Pharmaceutical Design, 2013; 19(7):1201-1210.

Oertli M, Noben M, Engler DB, Semper RP, Reuter S, Maxeiner J, Gerhard M, Taube C, Müller A. Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance.Proc Natl Acad Sci U S A. 2013 Feb 4. 110(8):3047-3052.

Review articles

Müller A. and Rudel T. Modification of host cell apoptosis by viral and bacterial pathogens Int. J. Med. Microbiol. 291, 197-207 (2001). 

Monack, D., Müller, A. and Falkow, S. Persistent bacterial infections: the interface of the pathogen and the host immune system. Nature Rev. Microbiol. 2, 747-765 (2004). 

Müller, A., Falkow, S. and Amieva, M.R. Helicobacter pylori and gastric cancer: what can be learned by studying the response of gastric epithelial cells to the infection? Special gastric cancer edition of Cancer Epidemiology, Prevention and Biomarkers 14, 1859-1964 (2005).

Müller, A., Sayi, A. and Hitzler, I. Protective and pathogenic functions of T-cells are inseparable during the Helicobacter-host interaction. Discovery Medicine 8, 68-73 (2009).

Müller, A. and Solnick, J. Inflammation, Immunity and Vaccines for Helicobacter. Helicobacter 2011 Sep;16, 26-32.

Müller, A., Oertli, M. and Arnold, I.C. H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection. Cell Communication and Signaling, 9, 25(2011).

Arnold, I.C., Hitzler, I. and Müller, A. The immunomodulatory properties of Helicobacter pylori confer protection against allergic and chronic inflammatory disorders. Frontiers in Cellular and Infection Microbiol. 2:10. (2012)

Müller, A. Multi-step activation of the Helicobacter pylori effector CagA. Journal of Clinical Investigation 122, 1192-5.(2012)

Schmid C, Müller A. FoxD3 Is a Novel, Epigenetically Regulated Tumor Suppressor in Gastric Carcinogenesis. Gastroenterology. 2012 Nov 16; 144(1):22-25.

Salama, Nina R; Hartung, Mara L; Müller, Anne (2013). Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nature Reviews. Microbiology: 11(6):385-99

Book chapter

Müller A. The pathogenesis of MALT lymphoma. One chapter in a text book on gastric cancer. Springer University Press. (2008).

Group Müller