Publications

ZORA Publication List

Publications

• 2025

  • Journal Article

    • Herbst, Michael; Köksal, Hakan; Brunn, Silvan; Zanetti, Dominik; Domocos, Ioana; De Stefani, Viola; Gatti, Marco; Vivalda, Francesca; Pereira, Paulo; Nater, Marc; Cecconi, Virginia; Sartori, Alessandro A; van den Broek, Maries (2025). Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells. Cell Reports, 44(4):115510.
    • Vivalda, F., Gatti, M., Manfredi, L., Dogan, H., Porro, A., Collotta, G., Ceppi, I., von Aesch, C., van Ackeren, V., Wild, S., Steger, M., Canovas, B., Cubillos-Rojas, M., Riera, A., Cejka, P., Nebreda, A. R., Dibitetto, D., Rottenberg, S., & Sartori, A. (2025). The PIN1-p38-CtIP signalling axis protects stalled replication forks from deleterious degradation Nucleic Acids Research, 53(7), gkaf278. https://doi.org/10.1093/nar/gkaf278
    • Fishwick, K. M., Gomez Vieito, D., Greco, G., Collotta, G., Gatti, M., Kulik, A. A., Guérois, R., Corbeski, I., Phadte, A. S., Senoussi, I., Cejka, P., Pluciennik, A., Porro, A., & Sartori, A. (2025). Disruption of protein-protein interaction hotspots in the C-terminal domain of MLH1 confers mismatch repair deficiency NAR Cancer, 7(4), zcaf055. https://doi.org/10.1093/narcan/zcaf055

• 2024

  • Journal Article

    • Dibitetto, Diego; Liptay, Martin; Vivalda, Francesca; Dogan, Hülya; Gogola, Ewa; González Fernández, Martín; Duarte, Alexandra; Schmid, Jonas A; Decollogny, Morgane; Francica, Paola; Przetocka, Sara; Durant, Stephen T; Forment, Josep V; Klebic, Ismar; Siffert, Myriam; de Bruijn, Roebi; Kousholt, Arne N; Marti, Nicole A; Dettwiler, Martina; Sørensen, Claus S; Tille, Jean-Christophe; Undurraga, Manuela; Labidi-Galy, Intidhar; Lopes, Massimo; Sartori, Alessandro A; Jonkers, Jos; Rottenberg, Sven (2024). H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours Nature Communications, 15(1):4430.

• 2022

  • Journal Article

    • Bolck, Hella A; Przetocka, Sara; Meier, Roger; von Aesch, Christine; Zurfluh, Christina; Hänggi, Kay; Spegg, Vincent; Altmeyer, Matthias; Stebler, Michael; Nørrelykke, Simon F; Horvath, Peter; Sartori, Alessandro A; Porro, Antonio (2022). RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor Cells, 11:643.

• 2021

  • Journal Article

    • Goold, Robert; Hamilton, Joseph; Menneteau, Thomas; Flower, Michael; Bunting, Emma L; Aldous, Sarah G; Porro, Antonio; Vicente, José R; Allen, Nicholas D; Wilkinson, Hilary; Bates, Gillian P; Sartori, Alessandro A; Thalassinos, Konstantinos; Balmus, Gabriel; Tabrizi, Sarah J (2021). FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease Cell Reports, 36(9):109649.
    • Kratz, Katja; Artola-Borán, Mariela; Kobayashi-Era, Saho; Koh, Gene; Oliveira, Goncalo; Kobayashi, Shunsuke; Oliveira, Andreia; Zou, Xueqing; Richter, Julia; Tsuda, Masataka; Sasanuma, Hiroyuki; Takeda, Shunichi; Loizou, Joanna I; Sartori, Alessandro A; Nik-Zainal, Serena; Jiricny, Josef (2021). FANCD2-associated nuclease 1 partially compensates for the lack of Exonuclease 1 in mismatch repair Molecular and Cellular Biology, 41(9):e0030321.
    • Porro, Antonio; Mohiuddin, Mohiuddin; Zurfluh, Christina; Spegg, Vincent; Dai, Jingqi; Iehl, Florence; Ropars, Virginie; Collotta, Giulio; Fishwick, Keri M; Mozaffari, Nour L; Guérois, Raphaël; Jiricny, Josef; Altmeyer, Matthias; Charbonnier, Jean-Baptiste; Pearson, Christopher E; Sartori, Alessandro A (2021). FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats Science Advances, 7(31):eabf7906.
    • Favalli, Nicholas; Bassi, Gabriele; Pellegrino, Christian; Millul, Jacopo; De Luca, Roberto; Cazzamalli, Samuele; Yang, Su; Trenner, Anika; Mozaffari, Nour L; Myburgh, Renier; Moroglu, Mustafa; Conway, Stuart J; Sartori, Alessandro A; Manz, Markus G; Lerner, Richard A; Vogt, Peter K; Scheuermann, Jörg; Neri, Dario (2021). Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications Nature Chemistry, 13(6):540-548.
    • Mozaffari, Nour L; Pagliarulo, Fabio; Sartori, Alessandro A (2021). Human CtIP: A 'double agent' in DNA repair and tumorigenesis Seminars in Cell & Developmental Biology, 113:47-56.
    • Deshmukh, Amit L; Porro, Antonio; Mohiuddin, Mohiuddin; Lanni, Stella; Panigrahi, Gagan B; Caron, Marie-Christine; Masson, Jean-Yves; Sartori, Alessandro A; Pearson, Christopher E (2021). FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders Journal of Huntington's Disease, 10(1):95-122.
    • Favalli, Nicholas; Bassi, Gabriele; Pellegrino, Christian; Millul, Jacopo; De Luca, Roberto; Cazzamalli, Samuele; Yang, Su; Trenner, Anika; Mozaffari, Nour L; Myburgh, Renier; Moroglu, Mustafa; Conway, Stuart J; Sartori, Alessandro A; Manz, Markus G; Lerner, Richard A; Vogt, Peter K; Scheuermann, Jörg; Neri, Dario (2021). Publisher Correction: Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications Nature Chemistry, 13(7):714.
    • Kuster, Anika; Mozaffari, Nour L; Wilkinson, Oliver J; Wojtaszek, Jessica L; Zurfluh, Christina; Przetocka, Sara; Zyla, Dawid; von Aesch, Christine; Dillingham, Mark S; Williams, R Scott; Sartori, Alessandro A (2021). A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection Science Advances, 7(8):eabc6381.

• 2020

  • Journal Article

    • Francica, Paola; Mutlu, Merve; Blomen, Vincent A; Oliveira, Catarina; Nowicka, Zuzanna; Trenner, Anika; Gerhards, Nora M; Bouwman, Peter; Stickel, Elmer; Hekkelman, Maarten L; Lingg, Lea; Klebic, Ismar; van de Ven, Marieke; de Korte-Grimmerink, Renske; Howald, Denise; Jonkers, Jos; Sartori, Alessandro A; Fendler, Wojciech; Chapman, J Ross; Brummelkamp, Thijn; Rottenberg, Sven (2020). Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining Cell Reports, 32(8):108068.
    • Bassi, Gabriele; Favalli, Nicholas; Vuk, Miriam; Catalano, Marco; Martinelli, Adriano; Trenner, Anika; Porro, Antonio; Yang, Su; Tham, Chuin Lean; Moroglu, Mustafa; Yue, Wyatt W; Conway, Stuart J; Vogt, Peter K; Sartori, Alessandro A; Scheuermann, Jörg; Neri, Dario (2020). A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks Advanced Science, 7(22):2001970.

• 2019

  • Journal Article

    • Porro, Antonio; Sartori, Alessandro A (2019). Context Matters: RNF168 Connects with PALB2 to Rewire Homologous Recombination in BRCA1 Haploinsufficiency Molecular Cell, 73(6):1089-1091.
    • Godau, Julia; Ferretti, Lorenza P; Trenner, Anika; Dubois, Emeline; von Aesch, Christine; Marmignon, Antoine; Simon, Lauriane; Kapusta, Aurélie; Guérois, Raphaël; Bétermier, Mireille; Sartori, Alessandro A (2019). Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair DNA repair, 77:96-108.
    • Trenner, Anika; Sartori, Alessandro A (2019). Harnessing DNA Double-Strand Break Repair for Cancer Treatment Frontiers in Oncology, 9:1388.

• 2018

  • Journal Article

    • Przetocka, Sara; Porro, Antonio; Bolck, Hella A; Walker, Christina; Lezaja, Aleksandra; Trenner, Anika; von Aesch, Christine; Himmels, Sarah-Felicitas; D’Andrea, Alan D; Ceccaldi, Raphael; Altmeyer, Matthias; Sartori, Alessandro A (2018). CtIP-mediated fork protection synergizes with BRCA1 to suppress genomic instability upon DNA replication stress Molecular Cell, 72(3):568-582.e6.
    • Cánovas, Begoña; Igea, Ana; Sartori, Alessandro A; Gomis, Roger R; Paull, Tanya T; Isoda, Michitaka; Pérez-Montoyo, Héctor; Serra, Violeta; González-Suárez, Eva; Stracker, Travis H; Nebreda, Angel R (2018). Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells Cancer Cell, 33(6):1094-1110.e8.
    • Trenner, Anika; Godau, Julia; Sartori, Alessandro A (2018). A short BRCA2-derived cell-penetrating peptide targets RAD51 function and confers hypersensitivity towards PARP inhibition Molecular Cancer Therapeutics, 17(7):1392-1404.

• 2017

  • Journal Article

    • Porro, Antonio; Berti, Matteo; Pizzolato, Julia; Bologna, Serena; Kaden, Svenja; Saxer, Anja; Ma, Yue; Nagasawa, Kazuo; Sartori, Alessandro A; Jiricny, Josef (2017). FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 Nature Communications, 8(1):1073.
    • Mordasini, Vanessa; Ueda, Seigo; Aslandogmus, Roberta; Berger, Christoph; Gysin, Claudine; Hühn, Daniela; Sartori, Alessandro A; Bernasconi, Michele; Nadal, David (2017). Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells OncoTarget, 8(4):6461-6474.

• 2016

  • Journal Article

    • Lafranchi, Lorenzo; Sartori, Alessandro A (2016). The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection Molecular & Cellular Oncology, 2(4):e1000696.
    • Himmels, Sarah-Felicitas; Sartori, Alessandro A (2016). Controlling DNA-end resection: an emerging task for ubiquitin and SUMO Frontiers in Genetics, 7:152.
    • Ferretti, Lorenza P; Himmels, Sarah-Felicitas; Trenner, Anika; Walker, Christina; von Aesch, Christine; Eggenschwiler, Aline; Murina, Olga; Enchev, Radoslav I; Peter, Matthias; Freire, Raimundo; Porro, Antonio; Sartori, Alessandro A (2016). Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection Nature Communications, 7:12628.

• 2015

  • Journal Article

    • Fontana, Andrea O; Augsburger, Marc A; Grosse, Nicole; Guckenberger, Matthias; Lomax, Anthony J; Sartori, Alessandro A; Pruschy, Martin N (2015). Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation Radiotherapy and Oncology, 116(3):374-380.
    • Hühn, D; Kousholt, A N; Sørensen, C S; Sartori, Alessandro A (2015). miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP Oncogene, 34(30):3977-3984.

• 2014

  • Journal Article

    • Lafranchi, Lorenzo; de Boer, Harmen R; de Vries, Elisabeth G E; Ong, Shao-En; Sartori, Alessandro A; van Vugt, Marcel A T M (2014). APC/CCdh1 controls CtIP stability during the cell cycle and in response to DNA damage The EMBO Journal, 33(23):2860-2879.
    • Murina, Olga; von Aesch, Christine; Karakus, Ufuk; Ferretti, Lorenza P; Bolck, Hella A; Hänggi, Kay; Sartori, Alessandro A (2014). FANCD2 and CtIP Cooperate to Repair DNA Interstrand Crosslinks Cell Reports, 7(4):1030-1038.
    • Grosse, Nicole; Fontana, Andrea O; Hug, Eugen B; Lomax, Antony; Coray, Adolf; Augsburger, Marc; Paganetti, Harald; Sartori, Alessandro A; Pruschy, Martin (2014). Deficiency in homologous recombination renders Mammalian cells more sensitive to proton versus photon irradiation International Journal of Radiation Oncology, Biology, Physics, 88(1):175-181.

• 2013

  • Journal Article

    • Sartori, Alessandro A; Steger, Martin (2013). Prolyl isomerization: A new PIN code for DSB repair Cell Cycle, 12(17):2717-2718.
    • Ferretti, Lorenza P; Lafranchi, Lorenzo; Sartori, Alessandro A (2013). Controlling DNA-end resection: a new task for CDKs Frontiers in Genetics, 4:99.
    • Hühn, Daniela; Bolck, Hella A; Sartori, Alessandro A (2013). Targeting DNA double-strand break signalling and repair: recent advances in cancer therapy Swiss Medical Weekly, 143:w13837.
    • Chapman, J Ross; Barral, Patricia; Vannier, Jean-Baptiste; Borel, Valérie; Steger, Martin; Tomas-Loba, Antonia; Sartori, Alessandro A; Adams, Ian R; Batista, Facundo D; Boulton, Simon J (2013). RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection Molecular Cell, 49(5):858-871.
    • Steger, Martin; Murina, Olga; Hühn, Daniela; Ferretti, Lorenza P; Walser, Reto; Hänggi, Kay; Lafranchi, Lorenzo; Neugebauer, Christine; Paliwal, Shreya; Janscak, Pavel; Gerrits, Bertran; Del Sal, Giannino; Zerbe, Oliver; Sartori, Alessandro A (2013). Prolyl isomerase PIN1 regulates DNA double-strand break repair by Counteracting DNA end resection Molecular Cell, 50(3):333-343.
    • Adelman, Carrie A; Lolo, Rafal L; Birkbak, Nicolai J; Murina, Olga; Matsuzaki, Kenichiro; Horejsi, Zuzana; Parmar, Kalindi; Borel, Valérie; Skehel, J Mark; Stamp, Gordon; D'Andrea, Alan; Sartori, Alessandro A; Swanton, Charles; Boulton, Simon J (2013). HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis Nature, 502(7471):381-384.

• 2012

  • Journal Article

    • Kousholt, Arne Nedergaard; Fugger, Kasper; Hoffmann, Saskia; Larsen, Brian D; Menzel, Tobias; Sartori, Alessandro A; Sørensen, Claus Storgaard (2012). CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation Journal of Cell Biology, 197(7):869-876.
    • Peña-Diaz, Javier; Bregenhorn, Stephanie; Ghodgaonkar, Medini; Follonier, Cindy; Artola-Borán, Mariela; Castor, Dennis; Lopes, Massimo; Sartori, Alessandro A; Jiricny, Josef (2012). Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells Molecular Cell, 47(5):669-680.

• 2011

  • Journal Article

    • Sharma, A; Bode, B; Wenger, R H; Lehmann, K; Sartori, Alessandro A; Moch, H; Knuth, A; von Boehmer, L; van den Broek, Maries (2011). γ-radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo PLoS ONE, 6(11):e28217.
    • Toller, I M; Neelsen, K J; Steger, M; Hartung, M L; Hottiger, M O; Stucki, M; Kalali, B; Gerhard, M; Sartori, Alessandro A; Lopes, Massimo; Müller, Anne (2011). Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells Proceedings of the National Academy of Sciences of the United States of America (PNAS), 108(36):14944-14949.

• 2010

  • Journal Article

    • Kratz, K; Schöpf, B; Kaden, S; Sendoel, A; Eberhard, R; Lademann, C; Cannavó, E; Sartori, Alessandro A; Hengartner, M O; Jiricny, J (2010). Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents Cell, 142(1):77-88.
    • Eid, W; Steger, M; El-Shemerly, M; Ferretti, L P; Pena-Diaz, J; König, C J; Valtorta, E; Sartori, Alessandro A; Ferrari, S (2010). DNA end resection by CtIP and exonuclease 1 prevents genomic instability EMBO Reports, 11(12):962-968.

• 2009

  • Journal Article

    • Zheng, L; Kanagaraj, R; Mihaljevic, B; Schwendener, S; Sartori, Alessandro A; Gerrits, B; Shevelev, I; Janscak, Pavel (2009). MRE11 complex links RECQ5 helicase to sites of DNA damage Nucleic Acids Research, 37(8):2645-2657.

• 2008

  • Journal Article

    • Huertas, P; Cortés-Ledesma, F; Sartori, Alessandro A; Aguilera, A; Jackson, S P (2008). CDK targets Sae2 to control DNA-end resection and homologous recombination Nature, 455:689-692.

• 2007

  • Journal Article

    • Sartori, Alessandro A; Lukas, C; Coates, J; Mistrik, M; Fu, S; Bartek, J; Baer, R; Lukas, J; Jackson, S P (2007). Human CtIP promotes DNA end resection Nature, 450(7169):509-514.

• 2005

  • Journal Article

    • Lingaraju, G M; Sartori, Alessandro A; Kostrewa, D; Prota, A E; Jiricny, J; Winkler, F K (2005). A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure Structure, 13(1):87-98.

• 2004

  • Journal Article

    • Sartori, Alessandro A; Lingaraju, G M; Hunziker, P; Winkler, F K; Jiricny, J (2004). Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases Nucleic Acids Research, 32(22):6531-6539.

• 2003

  • Journal Article

    • Sartori, Alessandro A; Jiricny, J (2003). Enzymology of base excision repair in the hyperthermophilic archaeon Pyrobaculum aerophilum Journal of Biological Chemistry, 278(27):24563-24576.

• 2002

  • Journal Article

    • Sartori, Alessandro A; Fitz-Gibbon, S; Yang, H; Miller, J H; Jiricny, J (2002). A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site The EMBO Journal, 21(12):3182-3191.
    • Hinks, J A; Evans, M C W; De Miguel, Y; Sartori, Alessandro A; Jiricny, J; Pearl, L H (2002). An iron-sulfur cluster in the family 4 uracil-DNA glycosylases Journal of Biological Chemistry, 277(19):16936-19640.
    • Yang, H; Chiang, J-H; Fitz-Gibbon, S; Lebel, M; Sartori, Alessandro A; Jiricny, J; Slupska, M M; Miller, J H (2002). Direct interaction between uracil-DNA glycosylase and a proliferating cell nuclear antigen homolog in the crenarchaeon Pyrobaculum aerophilum Journal of Biological Chemistry, 277(25):22271-22278.

• 2001

  • Journal Article

    • Sartori, Alessandro A; Schär, P; Fitz-Gibbon, S; Miller, J H; Jiricny, J (2001). Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum. Journal of Biological Chemistry, 276(32):29979-29986.