Publications

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2022
- Journal Article
  - Boleslavska, Barbora; Oravetzova, Anna; Shukla, Kaustubh; Nascakova, Zuzana; Ibini, Oluwakemi Ngozi; Hasanova, Zdenka; Andrs, Martin; Kanagaraj, Radhakrishnan; Dobrovolna, Jana; Janscak, Pavel (2022). DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells. Nucleic Acids Research, 50(21):12274-12290.
  - Larsen, Brian D; Benada, Jan; Yung, Philip Yuk Kwong; Bell, Ryan A V; Pappas, George; Urban, Vaclav; Ahlskog, Johanna K; Kuo, Tia T; Janscak, Pavel; Megeney, Lynn A; Elsässer, Simon J; Bartek, Jiri; Sørensen, Claus S (2022). Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress. Science, 376(6592):476-483.
  - Sakellariou, Despoina; Bak, Sara Thornby; Isik, Esin; Barroso, Sonia I; Porro, Antonio; Aguilera, Andrés; Bartek, Jiri; Janscak, Pavel; Peña-Diaz, Javier (2022). MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells. Cell Reports, 39(1):110602.
2021
- Journal Article
  - Nascakova, Zuzana; Boleslavska, Barbora; Urban, Vaclav; Oravetzova, Anna; Vlachova, Edita; Janscak, Pavel; Dobrovolna, Jana (2021). RAD51 Inhibition Induces R-Loop Formation in Early G1 Phase of the Cell Cycle. International Journal of Molecular Sciences, 22(7):3740.
2020
- Journal Article
  - Bauer, Michael; Nascakova, Zuzana; Mihai, Anca-Irina; Cheng, Phil F; Levesque, Mitchell P; Lampart, Simon; Hurwitz, Robert; Pfannkuch, Lennart; Dobrovolna, Jana; Jacobs, Melanie; Bartfeld, Sina; Dohlman, Anders; Shen, Xiling; Gall, Alevtina A; Salama, Nina R; Töpfer, Antonia; Weber, Achim; Meyer, Thomas F; Janscak, Pavel; Müller, Anne (2020). The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress. Nature Communications, 11(1):5117.
  - Andrs, Martin; Hasanova, Zdenka; Oravetzova, Anna; Dobrovolna, Jana; Janscak, Pavel (2020). RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription. Genes, 11(2):232.
  - Chappidi, Nagaraja; Nascakova, Zuzana; Boleslavska, Barbora; Zellweger, Ralph; Isik, Esin; Andrs, Martin; Menon, Shruti; Dobrovolna, Jana; Balbo Pogliano, Chiara; Matos, Joao; Porro, Antonio; Lopes, Massimo; Janscak, Pavel (2020). Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops. Molecular Cell, 77(3):528-541.e8.
2019
- Journal Article
  - Teloni, Federico; Michelena, Jone; Lezaja, Aleksandra; Kilic, Sinan; Ambrosi, Christina; Menon, Shruti; Dobrovolna, Jana; Imhof, Ralph; Janscak, Pavel; Baubec, Tuncay; Altmeyer, Matthias (2019). Efficient pre-mRNA cleavage prevents replication-stress-associated genome instability. Molecular Cell, 73(4):670-683.e12.
2017
- Journal Article
  - Mijic, Sofija; Zellweger, Ralph; Chappidi, Nagaraja; Berti, Matteo; Jacobs, Kurt; Mutreja, Karun; Ursich, Sebastian; Ray Chaudhuri, Arnab; Nussenzweig, Andre; Janscak, Pavel; Lopes, Massimo (2017). Replication fork reversal triggers fork degradation in BRCA2-defective cells. Nature Communications, 8:859.
  - Di Marco, Stefano; Hasanova, Zdenka; Kanagaraj, Radhakrishnan; Chappidi, Nagaraja; Altmannova, Veronika; Menon, Shruti; Sedlackova, Hana; Langhoff, Jana; Surendranath, Kalpana; Hühn, Daniela; Bhowmick, Rahul; Marini, Victoria; Ferrari, Stefano; Hickson, Ian D; Krejci, Lumir; Janscak, Pavel (2017). RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Molecular Cell, 66(5):658-671.e8.
  - Henrich, Sarah Marie; Usadel, Clemens; Werwein, Eugen; Burdova, Kamila; Janscak, Pavel; Ferrari, Stefano; Hess, Daniel; Klempnauer, Karl-Heinz (2017). Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling. Scientific Reports, 7:41663.
  - Urban, Vaclav; Dobrovolna, Jana; Janscak, Pavel (2017). Distinct functions of human RecQ helicases during DNA replication. Biophysical Chemistry, 225:20-26.
2016
- Journal Article
  - Piwko, Wojciech; Mlejnkova, Lucie J; Mutreja, Karun; Ranjha, Lepakshi; Stafa, Diana; Smirnov, Alexander; Brodersen, Mia M L; Zellweger, Ralph; Sturzenegger, Andreas; Janscak, Pavel; Lopes, Massimo; Peter, Matthias; Cejka, Petr (2016). The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. EMBO Journal Online, 35:2584-2601.
  - Urban, Vaclav; Dobrovolna, Jana; Hühn, Daniela; Fryzelkova, Jana; Bartek, Jiri; Janscak, Pavel (2016). RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. Journal of Cell Biology, 214(4):401-415.
  - Budhathoki, Jagat B; Maleki, Parastoo; Roy, William A; Janscak, Pavel; Yodh, Jaya G; Balci, Hamza (2016). A comparative study of g-quadruplex unfolding and DNA reeling activities of human RECQ5 helicase. Biophysical Journal, 110(12):2585-2596.
2015
- Journal Article
  - Burdova, Kamila; Mihaljevic, Boris; Sturzenegger, Andreas; Chappidi, Nagaraja; Janscak, Pavel (2015). The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks. Molecular Cell, 59(4):603-614.
  - Csefalvay, Eva; Lapkouski, Mikalai; Guzanova, Alena; Csefalvay, Ladislav; Baikova, Tatsiana; Shevelev, Igor; Bialevich, Vitali; Shamayeva, Katsiaryna; Janscak, Pavel; Kuta Smatanova, Ivana; Panjikar, Santosh; Carey, Jannette; Weiserova, Marie; Ettrich, Rüdiger (2015). Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme. PLoS ONE, 10(6):e0128700.
2014
- Journal Article
  - Sturzenegger, Andreas; Burdova, Kamila; Kanagaraj, Radhakrishnan; Levikova, Maryna; Pinto, Cosimo; Cejka, Petr; Janscak, Pavel (2014). DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA-end resection in human cells. Journal of Biological Chemistry, 289(39):27314-27326.
  - Chatterjee, Sujoy; Zagelbaum, Jennifer; Savitsky, Pavel; Sturzenegger, Andreas; Huttner, Diana; Janscak, Pavel; Hickson, Ian D; Gileadi, Opher; Rothenberg, Eli (2014). Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures. Nature Communications, 5:5556.
  - Budhathoki, Jagat B; Ray, Sujay; Urban, Vaclav; Janscak, Pavel; Yodh, Jaya G; Balci, Hamza (2014). RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP. Nucleic Acids Research, 42(18):11528-11545.

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