Header

Institute of Molecular Cancer Research Sartori Lab

Selected original publications

  1. Chen Y, Hu H, Shang X, Fishwick KM, Greco G, Xiao Q, Zhou Y, Huang Q, Jiang T, Huang X, Wang G, Zhen X, Xu G, Qin S, Sartori AA, Liu Y. “Structural insights into the MLH1-FAN1 interaction reveal an undiscovered binding interface in MLH1.” Nature Communications, accepted.
  2. Collotta G, Gatti M, Ungureanu I, van Ackeren V, Rannou E, Vivalda F, Gomez Vieito D, Fishwick KM, von Aesch C, Porro A, Ungerleider K, Heidari A, Guérois R, Harding RJ, Bischof S, Balmus G, Sartori AA. “USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion.” Nature Communications (2026), 17:3551. doi:10.1038/s41467-026-70051-9
  3. Fishwick KM, Gomez Vieito D, Greco G, Collotta G, Gatti M, Kulik AA, Corbeski I, Phadte AS, Senoussi I, Cejka P, Pluciennik A, Porro A, Sartori AA. “Disruption of protein-protein interaction hot-spots in the C-terminal domain of MLH1 confers mismatch repair deficiency.” NAR Cancer (2025), 7(4). doi:10.1093/narcan/zcaf055
  4. Vivalda F, Gatti M, Manfredi L, Dogan H, Porro A, Collotta G, Ceppi I, von Aesch C, van Ackeren V, Wild S, Steger M, Canovas B, Cubillos-Rojas M, Riera A, Cejka P, Nebreda AR, Dibitetto D, Rottenberg S, Sartori AA. “The PIN1-p38-CtIP signalling axis protects stalled forks from deleterious degradation.” Nucleic Acids Research (2025), 53(7). doi:10.1093/nar/gkaf278
  5. Bolck HA, Przetocka S, Meier R, von Aesch C, Zurfluh C, Hänggi K, Spegg V, Altmeyer M, Stebler M, Norrelykke SF, Horvath P, Sartori AA, Porro A. “RNAi screening uncovers a synthetic sick interaction between CtIP and the BARD1 tumor suppressor.” Cells (2022), 11(4):643. doi:10.3390/cells11040643
  6. Porro A, Mohiuddin M, Zurfluh C, Spegg V, Dai J, Iehl F, Ropars V, Collotta G, Fishwick K, Mozaffari NL, Guerois R, Jiricny J, Altmeyer M, Charbonnier JB, Pearson CE, Sartori AA. “FAN1-MLH1 interaction affects repair of DNA interstrand crosslinks and slipped-CAG/CTG repeats.” Science Advances (2021), 7(31):eabf7906. doi:10.1126/sciadv.abf7906
  7. Kuster A, Mozaffari NL, Wilkinson OJ, Wojtaszek JL, Zurfluh C, Przetocka S, Zyla D, von Aesch C, Dillingham MS, Williams RS, Sartori AA. “A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection.” Science Advances (2021), 7(8):eabc6381. doi:10.1126/sciadv.abc6381
  8. Godau J, Ferretti LP, Trenner A, Dubois E, von Aesch C, Marmignon A, Simon L, Kapusta A, Guerois R, Betermier M, Sartori AA. “Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair.” DNA Repair (2019), 77:96-108. doi:10.1016/j.dnarep.2019.03.011
  9. Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D'Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA. “CtIP-mediated fork protection synergizes with BRCA1 to suppress genomic instability upon DNA replication stress.” Molecular Cell (2018), 72(3):568-582. doi:10.1016/j.molcel.2018.09.014
  10. Trenner A, Godau J, Sartori AA. “A short BRCA2-derived cell-penetrating peptide targets RAD51 function and confers hypersensitivity to PARP inhibition.” Molecular Cancer Therapeutics (2018), 17(7):1392-1404. doi:10.1158/1535-7163.MCT-17-1156
  11. Porro A, Berti M, Pizzolato J, Bologna S, Kaden S, Saxer A, Ma Y, Nagasawa K, Sartori AA, Jiricny J. “FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2.” Nature Communications (2017), 8(1):1073. doi:10.1038/s41467-017-01074-6
  12. Ferretti LP, Himmels SF, Trenner A, Walker C, von Aesch C, Eggenschwiler A, Murina O, Enchev RI, Peter M, Freire R, Porro A, Sartori AA. “Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.” Nature Communications (2016), 7:12628. doi:10.1038/ncomms12628

Selected Reviews:

  1. Mozaffari NL, Pagliarulo F, Sartori AA. “Human CtIP: A ‘double agent’ in DNA repair and tumorigenesis.” Seminars in Cell & Developmental Biology (2021), 113:47–56. doi:10.1016/j.semcdb.2020.09.001
  2. Deshmuk AL, Porro A, Mohiuddin M, Lanni S, Panigrahi GB, Caron MC, Masson JY, Sartori AA, Pearson CE. “FAN1, a DNA repair nuclease, as a modifier of repeat expansion disorders.” Journal of Huntington's Disease (2021), 10(1):95–122. doi:10.3233/JHD-200448
  3. Trenner A, Sartori AA. “Harnessing DNA double-strand break repair for cancer treatment.” Frontiers in Oncology (2019), 9:1388. doi:10.3389/fonc.2019.01388